Advanced Water Management Centre

AWMC Seminar Program: Unravelling Roles of Non-Antibiotic Pharmaceuticals on Dissemination of Antibiotic Resistance in Environmental Settings



The spread of antibiotic resistance represents a global threat to public health, which is killing at least 700,000 people around the world every year. Our common understanding is that the overuse and misuse of antibiotics in clinic settings, agriculture, and aquaculture has led to the spread of antibiotic resistance. As a result, researchers have mostly focused on clinically relevant high-level resistance induced by antibiotics. However, there is no study to demonstrate whether non-antibiotic pharmaceuticals could cause antibiotic resistance or not.

Our study is working to fill critical knowledge gaps in antibiotic resistance induced by common pharmaceuticals. Different categories of pharmaceuticals will be applied to test whether they can enhance horizontal transfer of antibiotic resistance genes (ARGs) within and across genera. Pure culture and mixed culture experimental-conditions will be set up to determine the ARGs transfer pathways. Both phenotypic experiments (such as transfer frequency, cell membrane permeability, reactive oxygen species (ROS) generation) and molecular analyses (such as DNA-, RNA-sequencing and proteomics analysis) will be conducted to elucidate the relevant mechanisms. Our findings will be a wake-up call to start re-evaluating the potential antibiotic-like roles induced by non-antibiotic drugs.


Speaker Bio

Yue received her Bachelor Degree in Water Supply and Drainage Engineering from Taiyuan University of Technology in 2013. Thereafter, she obtained her Master study in Municipal Engineering from Tianjin University in 2016. In 2017, she moved to the Advanced Water Management Centre to pursue her PhD degree.

Event Details
Date & Time: 
Friday, 02 February 2018
9am - 10am
Venue: AIBN Building 75, Level 1 Seminar Room

Event Contact: